Suguru Nakamura

Suguru Nakamura

Associate Professor
Department of Biological Sciences
2112D Biology Building
Murray State University
Murray, KY 42071

Office: 270-809-6185 / BG-2112D
Lab: 270-809-3195 / BG-2118
Email: suguru.nakamura@murraystate.edu

Teaching Classes:
Human Anatomy (BIO 227/228)
Human Physiology (BIO 229/230)
Medical Cell Biology (BIO 504)
Pathophysiology (BIO 522)
International Experience in Biomedical Sciences (BIO 531)
Slides


Dr. Nakamura’s research is focused on the physiological studies of acid-base balance and ion transports in the kidney. His studies include the characterization of the signal transduction pathway involved in stimulation of a potassium-dependent acid secretion transporter (H+-K+-ATPase) and a potassium-independent acid secretion transporter (H+-ATPase) in response to changes in many animal models, such as diabetes and hypertension. Recently, his laboratory demonstrated an essential link between these acid secretion transporters and the glycolysis metabolic pathway. This link may be crucial in understanding the pathophysiological mechanism of diabetes and the metabolism of cancer cells, and the ability of cells to survive during an interruption in blood flow. The majority of his laboratory research utilizes in vitro microperfusion of isolated single kidney tubule in animal models that include transgenic mice. Advanced techniques used in Dr. Nakamura’s laboratory include fluorescent ratio imaging, imaging analysis, cell membrane potential, and bicarbonate or ammonia flux measurements. Undergraduate and graduate students working in this laboratory will have an opportunity to apply many advanced methods in physiology, biochemistry, and recombinant DNA to understanding cellular regulation and molecular cell biology.
 

Selected Publications
1

Nakamura, Suguru, H. Amlal, J. Galla, and M. Soleimani. Colonic H+ -K+ -ATPase is induced and mediates increased HCO3- reabsorption in inner medullary collecting duct in potassium depletion. Kidney Int. 54: 1233-1239, 1998.
2

Nakamura, Suguru, Z. Wang, J. Galla, and M. Soleimani. K+ depletion increases HCO3-reabsorption in OMCD by activation of colonic H+ -K+ -ATPase. Am. J. Physiol. 274 (Renal Physiol. 43): F687-692, 1998.
3

Nakamura, Suguru, H. Amlal, J. Galla, and M. Soleimani. NH4+ secretion in inner medullary collecting duct in potassium deprivation: Role of colonic H+-K+-ATPase. Kidney Int. 56: 2160-2167, 1999.
4

Nakamura, Suguru, H. Amlal, PJ Schultheis, J. Galla, GE Shull and M. Soleimani. HCO3-reabsorption in renal collecting duct of NHE-3 deficient mouse: a compensatory response. Am. J. Physiol. 276 (Renal Physiol. 6): F914-921, 1999.
5

Nakamura, Suguru, H. Amlal, M. Soleimani, and J. Galla. Pathways for HCO3- reabsorption in mouse medullary collecting duct segments. J Lab Clin Med. 136: 218-23, 2000.
6

Zhou, Xiaoming, S. Nakamura, SL. Xia, and CS. Wingo. Increased CO2 stimulates K/Rb reabsorption mediated by H-K-ATPase in CCD of potassium-restricted rabbit. Am. J. Physiol. 281 (Renal Physiol.): F366-373, 2001.
7

Nakamura, Suguru. Glucose activates H(+)-ATPase in kidney epithelial cells. Am. J. Physiol. 287 (Cell Physiol.): C97-105, 2004
8

Nakamura, Suguru. H+-ATPase activity in selective disruption of H+-K+-ATPase alpha 1 gene of mice under normal and K-depleted conditions. J Lab Clin Med. 147: 45-51, 2006.
9

Xu J, Song P, Nakamura S, Miller M, Barone S, Alper SL, Riederer B, Bonhagen J, Arend LJ, Amlal H, Seidler U, Soleimani M. Deletion of the chloride transporter Slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. Journal of Biological Chemistry 284(43):29470-29479, 2009
 
Back to Faculty Page | Biology Home Page | CSET Home Page
Last modified September, 2011